The Region of Molise has deep Italic roots. Its history is closely connected to the neighbour Region of Abruzzo.
Lower Paleolithic settlements were found here. The most ancient site of this region is called "la Pineta". It's 500.000 years old and is close to Isernia. Lots of artifacts were found here improved with many bones of large mammals. Besides, relics from Paleolithics and Copper Age were found in Trasacco.
Molise has inhabited by many populations similiar in ethnicity and culture sine V Century BC and more groups took place here during IV Century BC: the Frentani, the Samnites and the Pentri. These folks were able to strongly withstand against Romans offensive for a long time and that's the reason why a lot of weapons of the time were found in the small temple of Pietrabbondante Sanctuary, the main sacred place of Samnites.